منابع مشابه
Cell competition
It is self-evident that cell–cell interactions play important roles in multicellular organisms. Genetic mosaics and chimeras, containing cells of distinct genotypes, have long provided an important way to identify and study these interactions. Beginning in the 970s, genetic mosaic studies in Drosophila began to reveal an unexpected and intriguing phenomenon called ‘cell competition’, in which o...
متن کاملFIRST SESSION: CELL COMPETITION IN DEVELOPMENT Genetic analysis of Minute cell competition
FUNDACIÓN RAMÓN ARECES FIRST SESSION: CELL COMPETITION IN DEVELOPMENT Genetic analysis of Minute cell competition Nicholas Baker Albert Einstein College. New York. USA. Ribosomal protein genes are usually haploinsufficient and their mutations lead to dominant growth defects. Heterozygous cells are out-competed by wild type cells. We isolated mutations that prevent the loss of Minute cells from ...
متن کاملMyc, cell competition, and compensatory proliferation.
The proto-oncogene Myc is already known to affect many cellular processes, but recent experiments in the fruit fly Drosophila melanogaster have revealed yet a new facet of Myc. Neighboring cells were shown to compare their Myc levels and the losers (cells with lower Myc activity) were actively eliminated. This phenomenon is called "cell competition," and it seems to be part of a developmental s...
متن کاملEngulfment Is Required for Cell Competition
Genetic mosaics that place cells in competition within tissues may model features of tissue repair and tumor development and may reveal mechanisms of growth regulation. In one example, normal cells eliminate "Minute" cells that have reduced ribosomal protein gene dose and grow at their expense, replacing the Minute cells within developing compartments. We describe genes that are required by wil...
متن کاملMechanisms of cell competition: Themes and variations
Cell competition is the short-range elimination of slow-dividing cells through apoptosis when confronted with a faster growing population. It is based on the comparison of relative cell fitness between neighboring cells and is a striking example of tissue adaptability that could play a central role in developmental error correction and cancer progression in both Drosophila melanogaster and mamm...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.11.030